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Oxycodone, sold under the brand name OxyContin (which is the extended release form) among others, is an opioid medication used for treatment of moderate to severe pain, and a common drug of abuse. It is usually taken by mouth, and is available in immediate-release and controlled-release formulations. Onset of pain relief typically begins within fifteen minutes and lasts for up to six hours with the immediate-release formulation. In the United Kingdom, it is available by injection. Combination products are also available with paracetamol (acetaminophen), ibuprofen, naloxone, and aspirin.
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Oxycodone Hydrochloride Common side effects include euphoria, constipation, nausea, vomiting, loss of appetite, drowsiness, dizziness, itching, dry mouth, and sweating. Severe side effects may include addiction, dependence, hallucinations, respiratory depression (a reduction in breathing), bradycardia, and low blood pressure. Those allergic to codeine may also be allergic to oxycodone. Use of oxycodone in early pregnancy appears relatively safe. Opioid withdrawal may occur if rapidly stopped. Oxycodone acts by activating the μ-opioid receptor. When taken by mouth, it has roughly 1.5 times the effect of the equivalent amount of morphine.
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Oxycodone Hydrochloride was first made in Germany in 1916 from thebaine. It is available as a generic medication. In 2017, it was the 52nd most commonly prescribed medication in the United States, with more than fifteen million prescriptions. A number of abuse-deterrent formulations are available, such as in combination with naloxone. Oxycodone is used for managing moderate to severe acute or chronic pain when other treatments are not sufficient. It may improve quality of life in certain types of pain. It is unclear if use in chronic pain results in improved quality of life or ongoing pain relief.
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Similarly to most other opioids, oxycodone increases prolactin secretion, but its influence on testosterone levels is unknown. Unlike morphine, oxycodone lacks immunosuppressive activity (measured by natural killer cell activity and interleukin 2 production in vitro); the clinical relevance of this has not been clarified.
Oxycodon; Dihydrohydroxycodeinon; Dihydron, Oxycodeinon; Dihydroxycodeinon; Oxicodona; Dihidrohidroxicodeinona; Dihidrona, Oxicodeinona; Dihidroxicodeinona; Оксикодон; Дигидрогидроксикодеинон; Дигидрон, оксикодеинон; Дигидроксикодеинон; Dihydrohydroxycodeinone; Dihydrone;Oxycodeinone; Dihydroxycodeinone; CAS 76-42-6
25 g, 100 g, 500 g, 1000 g