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Buy Sodium Barbital Online – Get Veronal Sodium Price Online – CAS 144-02-5

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Buy Sodium Barbital Online – Get Veronal Sodium Price Online – CAS 144-02-5

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Sodium Barbital (or barbitone), marketed under the brand names Veronal for the pure acid and Medinal for the sodium salt, was the first commercially available barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s.

Description

Sodium Barbital (or barbitone), marketed under the brand names Veronal for the pure acid and Medinal for the sodium salt, was the first commercially available barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s. The chemical names for barbital are diethylmalonyl urea or diethylbarbituric acid; hence, the sodium salt (known as medinal, a genericised trademark in the United Kingdom) is known also as sodium diethylbarbiturate.

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Other names: Veronal; barbitone

Sodium Barbital, then called “Veronal”, was first synthesized in 1902 by German chemists Emil Fischer and Joseph von Mering, who published their discovery in 1903. Barbital was prepared by condensing diethylmalonic ester with urea in the presence of sodium ethoxide, or by adding at least two molar equivalents of ethyl iodide to the silver salt of malonylurea (barbituric acid) or possibly to a basic solution of the acid. The result was an odorless, slightly bitter, white crystalline powder.

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Sodium Barbital was marketed in 1904 by the Bayer company as “Veronal”. A soluble salt of barbital was marketed by the Schering company as “Medinal.” It was dispensed for “insomnia induced by nervous excitability”. It was provided in either crystal form or in cachets (capsules). The therapeutic dose was ten to fifteen grains (0.6-1 grams). 3.5 to 4.4 grams (55 to 68 grains) is the deadly dose but sleep has also been prolonged up to ten days with recovery.

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Barbital was considered to be a great improvement over the existing hypnotics. Its taste was slightly bitter, but better than the strong, unpleasant taste of the commonly used bromides. It had few side effects, and its therapeutic dose was far below the toxic dose. However, prolonged usage resulted in tolerance to the drug, requiring higher doses to reach the desired effect. Solutions of sodium barbital have also been used as pH buffers for biological research, e.g., in immunoelectrophoresis or in fixative solutions. As barbital is a controlled substance, barbital-based buffers have largely been replaced by other substances.

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CAS 144-02-5; Barbital de sodio; Barbital-Natrium; Барбитал натрия; Barbital sodium; 5,5-диэтилбарбитурат натрия; Natrium 5,5-Diethylbarbiturat; 5,5-dietilbarbiturato de sodio; Sodium 5,5-diethylbarbiturate; Barbitona de sodio; Natriumbarbiton; Embinal; Natrinal; Nervoseton; Барбитон натрия; Эмбинал; Натринальный; Нервосетон

 

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50 g, 100 g, 500 g, 1000 g

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